Peripheral neuropathies associated with drugs and toxins

Positive or negative sensory findings including numbness, tingling, neuropathic pain, and stocking glove pattern sensory loss.

https://now.aapmr.org/peripheral-neuropathies-associated-wit...

Physical examination revealed bilateral stocking pattern sensory loss, moderate hepatomegaly, and evidence of lipodystrophy, with pronounced central fat accumulation.

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Sensory symptoms include distal dysesthesias, pain and numbness. A characteristic pattern of numbness is one in which the distal portions of the nerves are first affected, the so-called "stocking-glove" pattern. This pattern occurs because nerve fibers are affected according to length of axon, without regard to root or nerve trunk distribution.

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Mechanisms of Chemotherapy-Induced Peripheral Neuropathy

Sensory symptoms usually develop first, involve the feet and hands and commonly present as a typical “glove and stocking” neuropathy with the most distal parts of the limbs exhibiting the greatest deficits.

In the subsequent part of this paper, we review the clinical picture of CIPN and the exact neurotoxicity mechanisms associated with individual drugs most commonly used in cancer chemotherapy, namely, platinum-based antineoplastics, immunomodulatory drugs (thalidomide), taxanes, epothilones (ixabepilone), vinca alkaloids and proteasome inhibitors (bortezomib).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471666/

or glove and stocking neuropathy/ neurotoxicity with bilateral stocking pattern