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Business, legal and financial interpreter & translator | Freelance,  Membro verificato | | Translation, Interpreting, Editing/proofreading, Website localization | | Specializzazione: | | Contabilità/Amministrazione | Affari/Commercio (generale) | | Finanza (generale) | Certificati, Diplomi, Licenze, CV | | Legale: Contratti | Brevetti | | Archeologia | Viaggi e Turismo | | Medicina (generale) |
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More Less | | Risposte a domande: 1860, Domande inviate: 26 Easy / 826 PRO, Punti PRO: 3428 | | Wire transfer | Traduzioni di prova presentate: 1Da Italiano a Inglese: Cheratopia anulare
Detailed field: Medicina (generale) | Testo originale - Italiano
Cheratopatia anulare associata a rettocolite ulcerosa e artrite psoriasica
INTRODUZIONE
La cheratopatia anulare rappresenta una rara patologia oculare, le cui manifestazioni tipiche sono caratterizzate da opacità stromali a forma di anello, prevalentemente localizzate nella media periferia corneale. Ascher 1 descrive il caso di un uomo di 39 anni in cui le opacità corneali bilaterali si associavano ad irite monolaterale idiopatica. Born 2 riporta due casi riguardanti una paziente di sesso femminile di 66 anni ed un uomo di 59aa in cui, all’anello di opacità stromale corneale, si associavano infiltrati marginali unilaterali. Più recentemente Melles 3 e Silvestri 4 hanno osservato tre casi di opacità corneale anulare, in un giovane ed in due donne anziane, in assenza di altre patologie oculari e sistemiche.
Per spiegare l’eziologia di tali cheratopatie , difficilmente identificabili in quadri noti di degenerazioni o distrofie corneali congenite o dismetaboliche, sono stati ipotizzati meccanismi di natura infiammatoria e/o immunologica o, talora, fattori degenerativi correlati all’età. 2,3,5.
Nel presente lavoro viene riportata l’inusuale presenza di un’opacità anulare bilaterale stromale della cornea in un paziente di sesso maschile di 30 anni affetto da rettocolite ulcerosa ed artrite psoriasica .Oltre alle comuni metodiche diagnostiche oftalmologiche, il presente caso è stato sottoposto ad un approfondimento con esame biomicroscopico ad ultrasuoni (UBM).
PAZIENTE E METODI
XX , sesso maschile , di anni 30. fu inviato nel Maggio 1999 al Servizio di Immunovirologia oculare del Dipartimento di Oftalmologia dell’Università “La Sapienza “ con diagnosi di cheratopatia bilaterale. L’anamnesi patologica remota e prossima evidenziava la presenza di artrite sieronegativa dall’età di tre anni caratterizzata da artralgie, congiuntivite, dolori addominali, trattata con corticosteroidi a dosaggi imprecisati. All’età di 21 anni venivano riscontrate lesioni psoriasiche diffuse agli arti ed al tronco mentre due anni dopo (a 23 anni) il paziente presentava un peggioramento della sintomatologia addominale e delle artralgie comparse nell’infanzia. Veniva pertanto formulata diagnosi di rettocolite ulcerosa associata ad artrite psoriasica e intrapreso un trattamento a base di ciclosporina A per via orale e di steroidi a dosaggi imprecisati. La ciclosporina A veniva sospesa in seguito ad un marcato rialzo della creatininemia e sostituita con salazopirina, mentre il cortisone veniva sospeso dopo … anni per osteoporosi e cataratta ed intrapreso trattamento con MTX interrotto dopo due anni per anemia. L’anamnesi oculare metteva in evidenza, oltre alla congiuntivite cronica associata alla sintomatologia sistemica insorta nell’infanzia, una cheratopatia bilaterale di natura imprecisata comparsa all’età di 22 anni.
Pochi mesi prima della nostra osservazione il paziente aveva presentato un peggioramento della sintomatologia oculare, caratterizzata da episodi di annebbiamento del visus, iperemia congiuntivale e fotofobia e per la quale aveva effettuato terapia topica con steroidi e ciclosporina A, senza giovamento. All’esame obiettivo oculare si evidenziava acuità visiva con correzione (quale?) pari a 10/10 per lontano e I carattere per vicino. L’esame biomicroscopico del segmento anteriore metteva in evidenza iperemia congiuntivele, reazione pericheratica ed ipertrofia papillare nella porzione tarsale bilaterali.
La cornea presentava opacità simmetriche nei due occhi caratterizzate da infiltrazione densa bianco-giallastra con margini interni regolari, parallele al limbus da ore 1 ad ore 11 in OD e con decorso anulare per 360° in OS (Fig. 1-2). Tra l’opacità ed il limbus residuava un’area di cornea trasparente di 2-3 millimetri con altri piccoli infiltrati di aspetto simile. In regione corneale centrale erano inoltre presenti alcune lesioni stromali con aspetto cristalliforme. L’esame del cristallino evidenziava in ambo gli occhi opacità sottocapsulare posteriore mentre il fondo oculare, mal esplorabile a causa dell’opacità dei mezzi diottrici appariva nella norma. Non si evidenziavano segni di flogosi uveale.
La biomicroscopia ad ultrasuoni (UBM mod.840, Zeiss-Humphrey,San Leandro) evidenziava nell’occhio destre ,in tutte le scansioni radiali da ore 1 ad ore 11, un’ area di iperetlessività intrastromale vagamente ovalare e con contorni irregolari che determinava lieve ombreggiamento sottostante.A livello della lesione il profilo superficiale e profondo della membrana corneale non risultava alterato. Mentre la linea ad alta riflettività dell’epitelio era ben demarcata, quella sottostante corrispondente alla membrana di Bowman ,era mal distinguibile.In alcune scansioni la lesione stremale si approfondiva fino a sfiorare la membrana di Descemet.
Nelle scansione radiali da ore 11 ad ore 1 la cornea presentava un aspetto ultrabiomicroscopio normale. L’occhio sinistro presentava lo stesso quadro esteso però per 360 gradi.
Gli esami del film lacrimale quali il test Break-up-time e il test di Shirmer apparivano nella norma, l’esame batteriologico ed istologico ottenuti da tampone e scraping congiuntivali risultarono negativi per germi aerobi, anaerobi ,virus, clamidie e acanthamoeba, rivelando solo un tappeto di granulociti neutrofili integri e disfatti. Gli esami ematochimici non mostravano alterazioni ad eccezione della elevazione della velocità di eritrosedimentazione (85 mm 1a h) e della riduzione della sideremia (22 mg./dl.) L’assetto glucidico, lipidico e proteico, i livelli del calcio e del fosfato nel sangue e nelle urine e i test sierologici per la sarcoidosi (ACE test) e per la sifilide (VDRL e TPHA) apparivano nella norma.
Veniva prescritta terapia con steroidi in collirio. Tale trattamento venne in seguito sospeso poiché non si osservarono modificazioni del quadro clinico nei 6 mesi di follow-up.
| Traduzione - Inglese
Ring keratopathy associated with ulcerative rectocolitis and psoriasic arthritis
INTRODUCTION
Ring keratopathy is a rare ocular pathology, the typical manifestations of which are characterized by stromal ring-shaped opacities, located primarily in the
mid corneal periphery. Ascher 1 describes the case of a 39 year-old man whose corneal bilateral opacities were associated to monolateral idiopathic iritis. Born 2 reports of two cases regarding a 66 year-old female patient and a 59 year-old male
in whom the stromal ring opacities of the cornea were associated with unilateral marginal infiltrations. More recently, Melles 3 and Silvestri 4 observed three cases of corneal ring opacity in a young man and in two elderly women, in the absence of other ocular and systemic pathologies.
In order to explain the aetiology of such keratopathies, not easily identifiable in known circles of degeneration or congenital or dysmetabolic corneal dystrophies,
mechanisms of an inflammatory and/or immunological nature, and even degenerative age-related factors have been hypothesized 2.3.5.
An unusual bilateral stromal ring opacity of the cornea has been reported in a 30 year-old male patient suffering from ulcerative rectocolitis and psoriatic arthritis. In addition to the standard ophthalmic diagnostic methods, the present case has undergone extensive investigation by
means of ultrasound biomicroscopic (UBM) examination.
PATIENT AND METHODOGY
XX - a 30 year-old male, was invited in May 1999 to the Ocular Immunovirology Service within the Department of Ophthalmology of "La Sapienza" University, his diagnosis being bilateral keratopathy. The remote and immediate future
pathological anamnesis highlighted the presence of sieronegative arthritis from age three, characterized by arthralgias, conjunctivitis, abdominal pain; treated with an unspecified dose of corticosteroids. At age 21, diffused psoriatic lesions of the limbs and trunk were noted, while two years later (at age 23) the patient
presented a worsening of the abdominal symptoms and of the arthralgias which had appeared during childhood. Thus a diagnosis of ulcerative rectocolitis, associated with psoriatic arthritis was made and a course of treatment initiated
based on the oral administration of Cyclosporin A and on an unspecified
dosage of steroids. The Cyclosporin A was suspended following a marked
increase in creatininemia and was substituted with Salazopyrine, while the cortisone was suspended after … years due to osteoporosis and cataract, and a new treatment was initiated with MTX (methotrexate) which was discontinued after two years due to anaemia. The ocular anamnesis highlighted, in addition to the chronic conjunctivitis associated to the systemic symptomology which appeared in childhood, a bilateral keratopathy of imprecise nature which appeared at age 22.
A few months prior to our observation, the patient had presented a worsening of the ocular symptomology, characterised by episodes of blurred vision, conjunctival hyperemia and photophobia for which he had undergone topical treatment with steroids and Cyclosporin A, with no improvement. The objective ocular examination revealed an acuity of vision with correction (which?) equal to 10/10 for distance and 1 character for near. The biomicroscopic examination of the anterior segment highlighted conjunctival hyperemia, perikeratic reaction and papillary hypertrophy in the bilateral tarsal portion.
The cornea presented symmetric opacities in each eye, characterized by a dense yellow-white infiltration with regular internal margins, parallel to the limbus from 1 to 11 o'clock sectors in the right eye and with an anular course extending over
360 degrees in the left eye (Figures 1-2). Between the opacity and the limbus, there was a residual 2-3 mm area of transparent cornea with other small infiltrations of a similar appearance. In the central area of the cornea there were also a few stromal lesions which were crystalline in appearance. Examination of the crystalline lens disclosed posterior subcapsular opacity of both eyes, while the ocular fundus, although difficult to explore due to the dioptric media opacity, appeared normal. No signs of posterior uveitis were revealed.
The ultrasound biomicroscopy (UBM mod. 840, Zeiss-Humphrey, San Leandro) of the right eye, revealed an area of interstromal hyperreflexia of a vaguely oval form with irregular contours, which caused a mild underlying, shadow in all radial scans of the 1 to 11 o'clock sectors. With regards to the lesion, the superficial and deeper profiles of the corneal membrane resulted unaltered. While the highly reflective line of the epithelium was well defined, the underlying line corresponding to Bowman's membrane, was difficult to distinguish. In several scans the stremal lesion was so deep as to touch upon Descemet's Membrane. Radial scans of the 11 to 1 o'clock sectors, presented a cornea of normal ultrabiomicroscopic appearance. The left eye presented the same manifestations, but extending over 360 degrees.
Examinations of the tear film such as the tear break-up-time test and Shirmer's test appeared normal, the bacteriological and histological examination obtained via conjunctival swab and conjunctival scraping proved negative for aerobic and anaerobic germs, viruses, chlamydiae and acanthamoebae, revealing only a
"carpet" of intact and impaired neutrophilic granulocytes. Haematochemical examinations showed no alterations with the exception of an increased eritrosedimentation rate (85 mm 1st hr) and in the reduction of sideremia (serum iron levels) (22mg/dl). The organization of glucids, lipids and proteins, the
calcium and phosphate levels in the blood and urine and the serum testing for sarcoidosis (ACE test) and for syphilis (VDRL and TPHA) appeared normal.
A treatment based on steroids and eyedrops was prescribed. Such treatment was later discontinued as no alteration to the clinical picture was observed during the 6 months of follow-up.
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More Less | | OTHER-Institute of Linguists | | Anni di esperienza nella traduzione: 18 Registrato in ProZ.com: Nov 2002. Membro ProZ.com da: Apr 2005. | | Da Inglese a Italiano (Chartered Institute of Linguists, verified)
Da Italiano a Inglese (Chartered Institute of Linguists, verified)
| | Chartered Institute of Bankers Scotland, IOL | | Adobe Acrobat, Microsoft Excel, Microsoft Word, Powerpoint, SDL TRADOS | | CV available upon request | | Ivana UK endorses ProZ.com's Professional Guidelines. | | Informazioni sull'utente
Background:
I have spoken both Italian and English since birth and consider myself to be truly bilingual, although my predominant language is currently English. I attended primary school in Italy; secondary school and university in Scotland where I studied French, Spanish and Portuguese as well as philosophy, psychology and classical civilisation of Greece. (I also studied Latin to Higher Grade level). A further 8 years were spent in Italy working as a tri-lingual tour guide and interpreter/translator before returning to Scotland 7 years ago.
I have been actively interpreting and translating for a number of years, both in Italy (Tuscany) and Scotland (Edinburgh and Glasgow).
I also worked for 6 years as a manager within a major UK bank.
In collaboration with a fully qualified native Italian translator, I now also offer English to Italian translations. Please contact me for a quote.
| Webster's Online Dictionary
The Rosetta Edition™ | | English Italian |
RECENT TRANSLATIONS:
Finance: Financial Statements and Notes to the Financial Statements, Directors' Reports, Articles and Memoranda of Association, Annual and Quarterly Reports, Report of the Board of Statutory Auditors, expenditure report, assessment detail report, review of non-productive assets, press releases, IPO, Offering Circular, stock market, Collective Property Investmnet Schemes, loan agreement, credit card agreements, loan applications, terms and conditions, insurance claims, insurance schedules
Legal: Service & Employment Contracts, Patents, Court Documentation, Witness Statement, Italian Civil Code, Code of Criminal Procedure, Constitution of the Italian Republic, Search and Seizure Warrant, Court Summons, Notice of Conclusion of Preliminary Investigations, Criminal Records, Agency Agreements, Fiduciary Contracts, Assumption of Debt Agreements, Service Contracts, EC-type Examination Certificates, Deed of Incorporation, Service Provision Contract, Special Power of Attorney
Certificates: birth certificates, marriage certificates, death certificates, criminal records, school diplomas, university degree certificates, professional qualification certificates, certificates of attendance, certificates of discharge from military service
Technical: technical manuals, instructions for use, product specifications, safety equipment, personal protective equipment, safety shoes brochure, industrial machines, folding machine manual, printing plate cleaning system manual, fancoils operating manual, calibration testing, household appliance brochures
Energy sector: Guidelines for the creation of a PPF curve for the Iberian market, statistical dynamic model software, the Italian photovoltaic market, the future of solar energy
Business:Policies and Procedures, training manuals, trade agreements, business correspondence, employment contracts, non-disclosure agreements, commercial policy, internal HR documentation, company profiles, company websites, minutes, internal control system
History:History and Cultural Identity of Trentino-Alto Adige/Sudtirol
Medical: Clinical trials, patient information leaflets, medical records, patent applications and articles on: Ring keratopathy associated with rectocolitis and ulcerative psoriasis; the effect of 904 nm laser on in vivo hematic circulation; suitability for cardiac transplants; treatment and prevention of the secondary effects of low level laser therapy in chemotherapy and radiation therapy, buffer solutions and pH-meter calibration
Automotive: Vehicle Registration Documents, diesel filter technical specifications and external interface requirements, automotive company risk control tracking system
Agriculture:Air sampling, analysis of atmospheric chloropicrin residue, irrigation system technical report, fertigation systems, water treatment units
General: travel & tourism brochures and websites, art, letters, lyrics, menus, websites, general correspondence, CVs
Professional Qualifications:
* Diploma in Financial Services - Chartered Institute of Bankers in Scotland
* DPSI (Diploma in Public Service Interpreting) - IoL (Institute of Linguists)
* Diploma in Business Administration - including Audio Typing Qualification
* RSA Stages I and II in Typing and Word Processing
Experience:
* Official Public Service interpreter/translator (Edinburgh City Council)
* Official police, Sheriff Court and High Court Interpreter
* Official conference and liason interpreter and translator for the Italian Cultural Institute (Edinburgh)
* Official interpreter and translator for the Italian Consulate (Edinburgh).
Specialisations:
My specialisations are in the financial and legal fields, although I have varied experience in medicine, public services, politics, local government, history, geology, architecture, technical, advertising, marketing, market research, tourism and general website translations.
COPYRIGHT: All information contained in this profile is the copyright of Ivana Micheli
Publications:
1991: "The Wind Cave", translation of "La Grotta del Vento"
Please view below to see my very first website translation (drawn from the above publication):
origins
name
discovery
itineraries
2007: "The Italian Cadastre of Artificial Cavities", translation of "Catasto nazionale delle cavità artificiali", B.A.R. (British Archaeological Reports), Hadrian Books
2008: "Adventures in Nature", translation of "Avventure in Natura", published by Children in Scotland
Interpreting skills:
liason interpreting, conference interpreting, telephone interpreting, simultaneous and consecutive.
Translation skills:
articles, reports, documents, manuals, books, websites, transcription, literature.
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Parole chiave: financial services, finance, law, financial statements, directors' reports, accounting, annual reports, company accounts, CVs, marriage certificates, birth certificates, government, politics, psychology, psychiatry, medical, psychology, literature, non-fiction, mining, minerals, military, fortifications, history, geography, archaeology, dental, automotive, tourism, clinical trials, pharmaceuticals, patents, transcription, interviews, reports, letters, recipes, documents, manuals, brochures, pamphlets, information booklets, websites
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